Posted from: Monday, March 02, 2015 - 05:30 PM - Present

New Indication for Imbruvica

The U.S. FDA approved Imbruvica (ibrutinib) as breakthrough therapy for Waldenström’s macroglobulinemia (WM), a rare type of non-Hodgkin lymphoma most common among older adults. Usually a slowly progressing type of cancer, WM causes enlargement of the liver, lymph nodes and spleen. Over production of M protein by the cancer cells causes blood to become dense, often leading to heart problems, nerve damage, stroke-like symptoms, vision changes and continual seepage of blood from the gums and nose. Imbruvica was previously indicated to treat patients who have had previous therapy for mantle cell lymphoma, who have tried other drugs for chronic lymphocytic leukemia (CLL), and who have CLL with a specific chromosomal abnormality. The recommended dosing for Imbruvica to treat WM is 420mg (three 140mg capsules) taken once a day.

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Actual drug patent expiration dates and a availability of new medications are subject to change due to patent litigation, settlement agreements, additional patents, exclusivities, and final FDA approval.  Distribution and availability of new medications at pharmacies may not occur immediately following FDA approval.  Patients are advised to speak with their healthcare professional or pharmacist regarding appropriateness as well as actual availability.


*This is provided for information only.  The reference to any medication above does not mean the medication is covered by your plan.


Last Updated Tuesday, October 22, 2019 - 12:27 AM.