Strensiq Approved for Hypophosphatasia
October 23, 2015 – The U.S. Food and Drug Administration granted approval for Strensiq (asfotase alfa) injection for subcutaneous use. Manufactured by Alexion Pharmaceuticals, Strensiq is indicated to be used to treat three types (pernatal-, infantile-, and juvenile- onset) of hypophosphatasia (HPP). HPP is a very rare inherited disorder of metabolism in which people who suffer from it lack an enzyme critical to the formation of bones and teeth. Untreated HPP may cause further complications such as deformed bones, breathing problems, growth delays, muscle weakness, pain, seizures, and death.
Strensiq is the first medication approved to treat HPP by replacement of the missing enzyme. The recommended dose for Strensiq is 2mg/kg, six times a week. Alexion Pharmaceuticals plans to launch Strensiq by late October and will be available through a limited network of specialty pharmacies.
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