Opdivo Gains New Indication
February 2, 2017 – The U.S.FDA approved Bristol-Myers Squibb’s Opdivo® (nivolumab), indicated for treating locally advanced or metastatic urothelial carcinoma (mUC) that has progressed either during or after platinum-containing chemotherapy. Opdivo may also be used within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. mUC is a form of bladder cancer that affects about 70,000 Americans a year, and more than one-half of patients experience a relapse after treatment. To treat mUC recurrence, the recommended dose of Opdivo is 240mg infused intravenously (IV) once every two weeks until the patient no longer responds or no longer tolerates side effects. Opdivo is a programmed death receptor-1 (PD-1) inhibitor, and as an immuno-oncology agent, it helps the body’s immune system attack cancer cells. Since its initial U.S. approval to treat metastatic melanoma in December 2014, Opdivo has been approved, either alone or in combination with other oncology drugs, to treat several other cancer types, including metastatic non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC).
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